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Friday, September 17, 2010


Even before Pasteur had proved by experiment that bacteria are the cause of some disease,many observant students expressed strong arguments for germ theory of diseases.
Even in the 16th century,it was thought that something could be transmitted from the diseased person to healthy person that induced disease.Many disease is seen to spread through population and were contagious and the unknown agent that did the spreading contagion.
The credit for the earliest discovery of pathogenic role of microorganisms probably goes to Augustino Bassi,who proved that the disease in silkworm was due to fungul injection.
Oliver Wendell Holmes in 1843 reported that puerperal sepsis a disease of child birth.
Holmes and ignaz in 1846 published a book for the antiseptic solutions.
L.pasteur found that fermentation of fruits and grains,resulting in alcohol,was brought by microbes and also determined that bacteria were responsible for the spoilage of wine during fermentation,and this work led to the germ theory of disease.
Joseph lister,concluded that wound infections too were due to microorganisms.He developed system to prevent microorganisms from entering wounds by the application of antiseptics.In 1876,a german physician,Robert Koch introduced methods for isolation of pure strains of bacteria.The most notable contribution of koch was the establishment of the casual relationship between a microorganism snd a specific disease applying a set of criteria referred to as koch’s postulates.And for many of his contributions he is known as father of medical microbiology.


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